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Articulation of three core metabolic processes in Arabidopsis: fatty acid biosynthesis, leucine catabolism and starch metabolism

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dc.contributor.author Mentzen, Wieslawa I
dc.contributor.author Peng, Jianling
dc.contributor.author Ransom, Nick
dc.contributor.author Nikolau, Basil J.
dc.contributor.author Wurtele, Eve Syrkin
dc.date.accessioned 2014-01-09T09:44:13Z
dc.date.available 2014-01-09T09:44:13Z
dc.date.issued 2008-07-11
dc.identifier.issn 1471-2229
dc.identifier.uri http://hdl.handle.net/11050/609
dc.description.abstract Elucidating metabolic network structures and functions in multicellular organisms is an emerging goal of functional genomics. We describe the co-expression network of three core metabolic processes in the genetic model plant Arabidopsis thaliana: fatty acid biosynthesis, starch metabolism and amino acid (leucine) catabolism. These co-expression networks form modules populated by genes coding for enzymes that represent the reactions generally considered to define each pathway. However, the modules also incorporate a wider set of genes that encode transporters, cofactor biosynthetic enzymes, precursor-producing enzymes, and regulatory molecules. We tested experimentally the hypothesis that one of the genes tightly co-expressed with starch metabolism module, a putative kinase AtPERK10, will have a role in this process. Indeed, knockout lines of AtPERK10 have an altered starch accumulation. In addition, the co-expression data define a novel hierarchical transcript-level structure associated with catabolism, in which genes performing smaller, more specific tasks appear to be recruited into higher-order modules with a broader catabolic function. Each of these core metabolic pathways is structured as a module of co-expressed transcripts that co-accumulate over a wide range of environmental and genetic perturbations and developmental stages, and represent an expanded set of macromolecules associated with the common task of supporting the functionality of each metabolic pathway. As experimentally demonstrated, co-expression analysis can provide a rich approach towards understanding gene function. IT
dc.language.iso en IT
dc.publisher BioMed Central IT
dc.relation.ispartof BMC Plant Biology IT
dc.relation.ispartofseries 8;76
dc.rights Attribuzione - Non commerciale - Non opere derivate 3.0 Italia *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/it/ *
dc.subject arabidopsis IT
dc.subject catabolism IT
dc.subject metabolic IT
dc.subject leucine IT
dc.subject amino acid IT
dc.title Articulation of three core metabolic processes in Arabidopsis: fatty acid biosynthesis, leucine catabolism and starch metabolism IT
dc.type Articolo IT
dc.description.status Pubblicato IT
dc.identifier.doi 10.1186/1471-2229-8-76 IT
dc.subject.een-cordis EEN CORDIS::SCIENZE BIOLOGICHE ::Ricerca sul genoma ::Bioinformatica IT
dc.subject.een-cordis EEN CORDIS::SCIENZE BIOLOGICHE ::Ricerca sul genoma ::Espressione genica, ricerca proteomica IT
dc.subject.program Program::Biomedicine::Bioinformatics (BI) IT


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Attribuzione - Non commerciale - Non opere derivate 3.0 Italia Attribuzione - Non commerciale - Non opere derivate 3.0 Italia