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Computational Prediction of Drug Cardiac Toxicity

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dc.contributor.other Fotia, Giorgio
dc.date.accessioned 2013-11-05T09:15:33Z
dc.date.available 2013-11-05T09:15:33Z
dc.date.issued 2008-06-01
dc.identifier.uri http://hdl.handle.net/11050/205
dc.description.abstract This project aims to model, simulate, and ultimately predict the impact of pharmacological compounds on the heart's rhythm using computer models. This will require advances in mathematical models of individual ion channels, which control how and when cells contract; tissue models, which encapsulate chemical processes and physical relationships at millions of separate points in the heart; and the numerical techniques, which must enable faster-than-real-time simulation of a living heart. By extending the frontiers of "in silico" experimentation, this project will allow to refine, replace and ultimately reduce the use of animals in pharmaceutical and other cardiac research. IT
dc.language.iso en IT
dc.subject cardiac IT
dc.subject heart IT
dc.subject drug IT
dc.subject toxicity IT
dc.subject arrhythmia IT
dc.subject large scale simulation IT
dc.subject numerical modeling IT
dc.title Computational Prediction of Drug Cardiac Toxicity IT
dc.title.alternative PREDICT IT
dc.type Scheda progetto CRS4 IT
dc.date.datafine 2011-05-31
dc.subject.een-cordis EEN CORDIS::ELETTRONICA, INFORMATICA E TELECOMUNICAZIONI::IT e applicazioni telematiche::Applicazioni per la salute IT
dc.subject.progetti Progetti::Bando competitivo/Grant::Finanziamento europeo/internazionale::EC FP7, FP6, FP5::PREDICT - Computational Prediction of Drug Cardiac Toxicity IT
dc.identifier.reference 224381 IT
dc.description.statusprogettoCRS4 Completato IT
dc.description.contributionbudgetCRS4 € 327.600 IT
dc.subject.program Program::Biomedicine::Bioinformatics (BI) IT
dc.identifier.websiteproject http://www.cs.ox.ac.uk/projects/preDiCT/ IT
dc.contributor.partner University of Oxford-United Kingdom-coordinator IT
dc.contributor.partner CRS4-Italy-contractor IT
dc.contributor.partner Aureus Pharma SA-France-contractor IT
dc.contributor.partner Universidad Politecnica de Valencia-Spain-contractor IT
dc.contributor.partner Fujitsu Laboratoires of Europe Limited-United Kingdom-contractor IT
dc.contributor.partner Glaxo Smith Kline Research and Development-United Kingdom-contractor IT
dc.contributor.partner Novartis Pharma-Switzerland-contractor IT
dc.contributor.partner F Hoffmann - LaRoche-Switzerland-contractor IT
dc.contributor.partner University of Szeged-Hungary-contractor IT

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